Blar i forfatter "Rosenkilde, MM"

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    • Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists 

      Mungalpara, Jignesh; Zachariassen, Zack George; Thiele, Stefanie; Rosenkilde, MM; Våbenø, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The cyclopentapeptide CXCR4 antagonist FC131 (cyclo(-Arg1-Arg2-2-Nal3-Gly4-D-Tyr5-), 2; 2-Nal = 3-(2-naphthyl)alanine) represents an excellent starting point for development of novel drug-like ligands with therapeutic potential in HIV, cancer, stem-cell mobilization, inflammation, and autoimmune diseases. While the structure–activity relationships for Arg1, Arg2, and Gly4 are well established, less ...